Protein Details: Neuronal acetylcholine receptor subunit alpha-2

Protein ID

ICDB_Pro_0840

Protein Name

Neuronal acetylcholine receptor subunit alpha-2

Gene Name

CHRNA2

Organism

Homo sapiens (Human)

Length

529 amino acids

AlphaFoldDB

AF-Q15822-F1-model_v4.pdb

Function

After binding acetylcholine;the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Sequence

MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI

PDB Structures

5FJV

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Epilepsy;Nocturnal Frontal Lobe;4 and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

Location

DOI ID

10.1523/jneurosci.13-02-00596.1993; 10.1074/jbc.m503746200; 10.1124/mol.105.017459; 10.1124/mol.114.096511; 10.1124/mol.114.096511err

RefSeq

NP_036964.3